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Li, Tzu-Hao; Liu, Chih-Wei; Lee, Pei-Chang; Huang, Chia-Chang; Lee, Kuei-Chuan; Hsieh, Yun-Cheng; Yang, Ying-Ying; Hsieh, Shie-Liang; Lin, Han-Chieh; Tsai, Chang-Youh

For steatotic livers , pharmacological approaches to minimize the hepatic neutrophil and macrophage infiltration, and cytokine and chemokine release in ischemia-reperfusion (IR) injury are still limited. Tumor necrosis factor (TNF)-α superfamily-stimulated pathogenic cascades and M1 macrophage/Kupffer cells (KC) polarization from Th1 cytokines are important in the pathogenesis of IR liver injury with hepatic steatosis (HS). Conversely, anti-inflammatory M2 macrophages produce Th2 cytokine (interleukin-4), which reciprocally enhances M2 polarization. Toll-like receptor 4-activated KCs can release proinflammatory mediators, skew M1 polarization and escalate liver IR injury. Decoy receptor 3 (DcR 3 ) could be potential agents simultaneously blocking the IR liver injury-related pathogenic changes and extend the survival of steatotic graft. Rats were fed with methionine and choline-deficient high-fat diet (MCD HFD) for 6 weeks to induce HS. Preliminary experiments with HS group and IR group were conducted, and either immunoglobulin G Fc protein or DcR3 analogue was treated for 14Âdays in all groups to evaluate the severity. In the Zucker rat -focused experiments, various serum and hepatic substances, M1 polarization, and hepatic microcirculation were assessed. We found that serum/hepatic DcR 3 levels were lower in nonalcoholic fatty liver disease patients with HS. DcR 3 a protected Zucker rats with HS from IR liver injury. The beneficial effects of DcR 3 a supplement were mediated by inhibiting hepatic M1 polarization of KCs, decreasing serum/hepatic TNFα, nitric oxide, nitrotyrosine, soluble TNF-like cytokine 1A, Fas ligand, and interferon-γ levels, neutrophil infiltration, and improving hepatic microcirculatory failure among rats with IR-injured steatotic livers . Additionally, downregulated hepatic TNF-like cytokine 1A/Fas-ligand and toll-like receptor 4/nuclear factor-κB signals were found to mediate the DcR 3 a-related protective effects of steatotic livers from

Counteraction of oxidative damage in the rat liver by an ancient grain (Kamut brand khorasan wheat).

Benedetti, Serena; Primiterra, Mariangela; Tagliamonte, Maria Chiara; Carnevali, Andrea; Gianotti, Andrea; Bordoni, Alessandra; Canestrari, Franco

We previously demonstrated in rat plasma the antioxidant protective effect of whole-grain bread, particularly when made from Kamut brand khorasan wheat. In the present study, we investigated the effects of the same experimental breads in rat liver using two different bread-making procedures (baker's yeast and sourdough fermentation). Rats were examined in the basal condition and after the administration of doxorubicin, a pro-oxidative agent. The following parameters were measured in liver homogenates: glutathione peroxidase and thioredoxin reductase activities, as antioxidant enzymes containing selenium; glutathione, α-tocopherol and β-carotene, as major non-enzymatic cell antioxidants; malondialdehyde and advanced oxidation protein products, as markers of oxidative damage to lipids and proteins, respectively. A histologic evaluation of liver tissue was also conducted. In agreement with our previous work, we observed a lower oxidative status and a different activity of glutathione peroxidase and thioredoxin reductase in rats fed the whole-grain Kamut khorasan bread than in rats fed the modern whole-grain durum wheat bread. Histologic evaluation of the hepatic tissue showed the onset of inflammation in response to doxorubicin only in rats fed the modern durum wheat bread. Our data confirm that bread made from whole-grain Kamut khorasan protects rats from oxidative stress better than bread made from whole-grain durum wheat. This is consistent with their different antioxidant profiles. The type of wheat used for bread-making appeared to be the main determinant of the observed protective effect. Copyright © 2012 Elsevier Inc. All rights reserved.

Bitcoin is a virtual currency, invented in October 2008 with the publication of “Bitcoin: A Peer-to-Peer Electronic Cash System,” a paper written by Satoshi Nakamoto (an alias. The real identity of Satoshi Nakamoto, the inventor(s?) of Bitcoin remains unknown, despite several well-publicized – and failed – attempts to “out” him). The code was released as open source in January 2009. (The next section of this guide examines the technology of Bitcoin and the blockchain in more detail.)

Thus, the Bitcoin network began in 2009 when Satoshi Nakamoto “mined” the first Bitcoins . Satoshi Nakamoto disappeared from the public – that is, from Bitcoin forums, papers, and code contributions – in April 2011. But even in Satoshi Nakamoto’s absence, Bitcoin continued to be developed and marketized, with the community working to address various issues with the code (including, for example, a technical glitch in 2013 that caused a fork in the blockchain ).

Bitcoin really took off in 2013, as more websites started accepting the currency, as investors started funding more Bitcoin-related startups ( more on investment in a section below), and as the price surged, hitting a record high of $1108 per Bitcoin in November of that year. But as its popularity grew, Bitcoin also faced scrutiny from law enforcement. The Department of Homeland Security shut down the Bitcoin exchange (formerly a Magic the Gathering exchange) Mt. Gox in 2013, which was at the time handling almost 70% of Bitcoin transactions. Mt. Gox declared bankruptcy the following year, amidst reports that some 744,000 bitcoins had been stolen from the site.

(Some of this history might seem a bit extraneous to a discussion about the blockchain in education, but I’d argue that it’s all important to consider when we think about the security, the infallibility, and most importantly ideology of blockchain – the latter the topic of a subsequent article in this research project .)

One Bitcoin is currently worth about $415 .

Other cryptocurrencies have been developed based on the Bitcoin technology – Litecoin and Dogecoin, for example – although their volatility has made some investors and pundits wary . That volatility – in the and in the community – has in recent months led many well-known Bitcoin developers to call it a failure . In a widely-circulated blog post published in January of this year, Mike Hearn wrote that “In the span of only about eight months, Bitcoin has gone from being a transparent and open community to one that is dominated by rampant censorship and attacks on bitcoiners by other bitcoiners.” In its coverage of the fallout, The New York Times cautions that “The current dispute, though, is a reminder that the Bitcoin software – like all computer code – is an evolving product of the human mind, and its deployment is vulnerable to human frailties and divergent ideals.”

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